The binding partner exploration of lncRNA MILIP in Burkitt Lymphoma

Description

Long non-coding RNA (lncRNA) is a type of RNA (» 200 nt) without coding potential, but has been proved playing essential roles in pathogenesis of numerous cancers. LncRNAs can act as cis/trans-regulators, chromatin scaffolds, translation regulators, and RNA splicing regulators, to regulate gene expression. Using high-throughput loss-of-function screening, we identified 3 tumor cell growth related lncRNAs in Burkitt lymphoma, including MILIP. MILIP is a Myc induced lncRNA which contributes to a range of tumors, i.e. renal cell carcinoma and neuroblastoma. In Burkitt lymphoma (BL), the loss of MILIP is harmful for cell growth and survival, but at present we are not clear about the regulation mechanism. In this SURF project, we plan to investigate the binding partners and regulated genes of MILIP to illustrate its pathogenic role in BL.

Period	15 Jun 2024 → 28 Aug 2024